Our results show for the first time that KMP6 potently regulates SCF-induced migration, p38 MAPK activation and inflammatory cytokines production through hindrance of SCF and c-kit binding in RPMCs.

In addition, SCF-induced inflammatory cytokine production was significantly inhibited by treatment with KMP6 or hesperidin ( P<0.05). KMP6 and hesperidin inhibited SCF-induced p38 MAPK activation. The ability of the SCF to enhance morphological alteration and F-actin formation was also abolished by treatment with KMP6 or hesperidin.

KMP6 and hesperidin significantly inhibited SCF-induced migration of RPMCs ( P<0.05). A molecular docking simulation showed that hesperidin, a major component of KMP6, controls the SCF and c-kit binding by interaction with the active site of the c-kit. To clarify a new effect of Pyeongwee-San extract (KMP6, a drug for indigestion) for the treatment of allergy, we investigated the effects of KMP6 on SCF-induced migration of rat peritoneal mast cells (RPMCs). Stem cell factor (SCF) as a mast cell chemotaxin induces mast cell migration. Accumulation of mast cells can be causally related to several allergic inflammations.

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